![]() ![]() ![]() Moreover, the changes of the salivary gland function in pre-diabetic stage known as insulin resistance are still unclear. Although several studies demonstrated that NIDDM has a positive correlation with impaired salivary gland function, including decreased salivary flow rate, some studies demonstrated contradictory findings. In non-insulin dependent diabetes mellitus (NIDDM), inadequate salivary gland function has been evidenced to closely associate with this abnormal glycemic control condition. Salivary gland dysfunction in several systemic diseases has been shown to decrease the quality of life in patients. Ittichaicharoen, Jitjiroj Chattipakorn, Nipon Chattipakorn, Siriporn C Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells. ![]() Additionally, we demonstrate that peripheral NK cells are not recruited to this organ even after the systemic infection has been controlled. Salivary gland NK cell effector functions are not regulated by iNKT or Treg cells, which are mostly absent in the salivary gland. During the course of murine cytomegalovirus (MCMV) infection, we found that salivary gland NK cells detect the infection and acquire activation markers, but have limited capacity to produce IFN-γ and degranulate. Using RORγt reporter mice and nude mice, we also show that the salivary gland NK cells are not lymphoid tissue inducer NK-like cells and are not thymic derived. Here we characterize a distinct NK cell population that resides in the salivary gland, uncommon to any described to date, expressing both mature and immature NK cell markers. However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Natural killer (NK) cells and CD8+ T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). Salivary Gland NK Cells Are Phenotypically and Functionally Unique ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |